New microscopy method achieves angstrom-scale localization precision with one laser
Researchers in the lab of Sam Peng, the Pfizer Inc.–Gerald Laubach Career Development Assistant Professor of Chemistry at MIT and a core institute member of the Broad Institute of MIT and Harvard, have developed a super-resolution imaging technology.
Researchers in the lab of Sam Peng, the Pfizer Inc.–Gerald Laubach Career Development Assistant Professor of Chemistry at MIT and a core institute member of the Broad Institute of MIT and Harvard, have developed a super-resolution imaging technology.
The short version
- It allows scientists to visualize molecular structures with angstrom-level localization precision—three orders of magnitude beyond the nanometer-scale limits of standard fluorescent dyes—while simplifying the imaging process.
- by Danielle Randall Doughty, Massachusetts Institute of Technology This article has been reviewed according to Science X's editorial process and policies .
- This work represents a shift in both optical materials and biological imaging.
What happened
An open-access description of the study was published July 27 in Nature Nanotechnology . For decades, the scientific community widely considered upconverting nanoparticles to be completely photostable and nonblinking.
Why it matters
"Our laboratory has long been interested in overcoming these limitations," Peng says.
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