Loss of Y chromosome in men could be an early warning sign of cancer
Dan Theodorescu, a physician-scientist at the University of Arizona Cancer Center, revealed that the loss of the Y chromosome in men's body tissue could pave the way for cancer to develop.

Dan Theodorescu, a physician-scientist at the University of Arizona Cancer Center, revealed that the loss of the Y chromosome in men's body tissue could pave the way for cancer to develop.
The short version
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- Each cell in men's bodies usually contains one X and one Y chromosome.
What happened
"Loss of Y" is a common genetic change in men in which an immune cell in the blood loses its Y chromosome. Previous studies showed that the loss of Y in blood cells elevated disease risk, but this study systematically profiled the loss of Y across normal, precancerous and malignant tissues in 11 major human organs.
Why it matters
"We were able to show that the loss of the Y chromosome is found in normal-appearing tissues adjacent to a tumor," said Theodorescu, the paper's senior author and Nancy C. and Craig M.
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